Invention Grant
- Patent Title: Recombinant Escherichia coli for producing succinate acid and application thereof
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Application No.: US14891776Application Date: 2014-05-23
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Publication No.: US10006063B2Publication Date: 2018-06-26
- Inventor: Xueli Zhang , Xinna Zhu , Hongtao Xu , Zaigao Tan
- Applicant: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
- Applicant Address: CN Tianjin
- Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES
- Current Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Tianjin
- Agency: Swanson & Bratschun, L.L.C.
- Priority: CN201310198953 20130524
- International Application: PCT/CN2014/078284 WO 20140523
- International Announcement: WO2014/187357 WO 20141127
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12P7/46 ; C12R1/19 ; C12N15/52 ; C12N9/02

Abstract:
The invention relates to the field of producing succinate by E. coli fermentation. Specifically, the invention provides an engineered recombinant E. coli for producing succinate, wherein said E. coli contains one or more of the following modifications: a) enhanced activity of the protein(s) encoded by the gene(s) involved in pentose phosphate pathway (PPP), b) enhanced activity of the protein encoded by sthA gene, and optionally c) mutant lpdA gene. The invention also relates to use of the engineered recombinant E. coli for producing succinate, and a method of using the engineered recombinant E. coli for producing succinate.
Public/Granted literature
- US20160097064A1 RECOMBINANT ESCHERICHIA COLI FOR PRODUCING SUCCINIC ACID AND APPLICATION THEREOF Public/Granted day:2016-04-07
Information query
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