Aspects of the disclosure provide a system for signal processing. The system includes a selection circuitry and a coordination detection circuitry. The selection circuitry is configured to receive data sets sampled at different time for a subject and select a plurality of data units from each data set that corresponds to regions of interests in the data set. The coordination detection circuitry is configured to receive the selected data units corresponding to the regions of interests over time, and detect a coordination of the regions of interests over time.