A sensor manager provides dynamic input fusion using thermal imaging to identify and segment a region of interest. Thermal overlay is used to focus heterogeneous sensors on regions of interest according to optimal sensor ranges and to reduce ambiguity of objects of interest. In one implementation, a thermal imaging sensor locates a region of interest that includes an object of interest within predetermined wavelengths. Based on the thermal imaging sensor input, the regions each of the plurality of sensors are focused on and the parameters each sensor employs to capture data from a region of interest are dynamically adjusted. The thermal imaging sensor input may be used during data pre-processing to dynamically eliminate or reduce unnecessary data and to dynamically focus data processing on sensor input corresponding to a region of interest.