A tissue insertion prosthesis system includes an expansible, multi-chambered implant for use in a tissue prosthesis receiving cavity, such that the implant includes an expansible envelope having a plurality of chambers. The system also includes a method of determining a size of a cavity at a site to be filled by a tissue prosthesis. Finally, the system includes a method to facilitate a removal of a biomaterial delivery device from an inflatable member that has been inserted into a cavity formed by the removal of a portion of a nuclear material from an intervertebral disc and to be filled by a tissue prosthesis.