Invention Grant
- Patent Title: Pyrazole, triazole and tetrazole orexin receptor antagonists
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Application No.: US15523256Application Date: 2015-10-27
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Publication No.: US10010539B2Publication Date: 2018-07-03
- Inventor: Nigel Liverton , Scott D. Kuduk , Douglas Beshore , Yunfu Luo , Na Meng
- Applicant: MERCK SHARP & DOHME CORP.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent J. Eric Thies; John C. Todaro
- Priority: WOPCT/CN2014/089934 20141030
- International Application: PCT/US2015/057439 WO 20151027
- International Announcement: WO2016/069512 WO 20160506
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D401/14 ; C07D409/14 ; C07D413/14 ; C07D471/02 ; A61K31/437 ; A61K31/454 ; A61K31/4545 ; A61K31/445
Abstract:
The present invention is directed to pyrazole, triazole and tetrazole compounds which are antagonists of orexin receptors. Such compounds are of the general structural formula I: The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
Public/Granted literature
- US20170319560A1 PYRAZOLE, TRIAZOLE AND TETRAZOLE OREXIN RECEPTOR ANTAGONISTS Public/Granted day:2017-11-09
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