Invention Grant
- Patent Title: Derivatives of GLP-1 like peptides, and uses thereof
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Application No.: US15278501Application Date: 2016-09-28
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Publication No.: US10010614B2Publication Date: 2018-07-03
- Inventor: Steffen Reedtz-Runge , Jacob Kofoed
- Applicant: Novo Nordisk A/S
- Applicant Address: DK Bagsvaerd
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Rosemarie R. Wilk-Orescan
- Priority: EP13175094 20130704
- Main IPC: A61K38/26
- IPC: A61K38/26 ; C07K14/605 ; A61K47/48

Abstract:
The invention relates to derivatives of GLP-1 like peptides which are C-terminally extended analogs of native GLP-1. The derivatives comprise two side chains, one at a position corresponding to position 42, and one at a position corresponding to position 18, 23, 27, 31, 36, or 38, wherein both positions are when compared to GLP-1(7-37). The side chains comprise a C19, C20, or C22 diacid protracting moiety and optionally a linker. The invention also relates to intermediate products in the form of novel GLP-1 analogs incorporated in the derivatives of the invention, as well as pharmaceutical compositions and medical uses of the derivatives. The derivatives have very long half-lives while maintaining a satisfactory potency, which makes them potentially suitable for once-monthly administration.
Public/Granted literature
- US20170007707A1 Derivatives of GLP-1 Like Peptides, and Uses Thereof Public/Granted day:2017-01-12
Information query
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