An overturning and shifting mechanism, comprising: a carrier platform (10) on which a first item-sensing device (12) is disposed; a transporting device (11) on which a second item-sensing device (13) is disposed; an overturning device (14) which is positioned between the carrier platform (10) and the transporting device (11) and which comprises a driving device (141) and a rotating arm (142), the rotating arm (142) being provided with a suction structure (15) thereon; and a control device which is connected with the first item-sensing device (12), the second item-sensing device (13), the driving device (141) and the suction structure (15), wherein according to sensing signals of the first item-sensing device (12) and the second item-sensing device (13), the control device controls the driving device to drive the rotating arm (142) to rotate reciprocatingly between the carrier platform (10) and the transporting device (11), while at the same time the control device controls sucking or releasing operation of the suction structure (15). The mechanism is mainly used in production process of display devices and solves problems in contaminations and deformations due to overturning and shifting of display panels by manual operations in the conventional arts.