Invention Grant
- Patent Title: Factor XIa inhibitors
-
Application No.: US15329635Application Date: 2015-07-23
-
Publication No.: US10011585B2Publication Date: 2018-07-03
- Inventor: Weiguo Liu , Scott D Edmondson , Zhuyan Guo , Alan Hruza , Sung-Sau So , Wanying Sun , Amjad Ali , Rongze Kuang , Ying-Duo Gao , Anthony K Ogawa
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; John C. Todaro
- International Application: PCT/US2015/041646 WO 20150723
- International Announcement: WO2016/018701 WO 20160204
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D401/14
Abstract:
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Public/Granted literature
- US20170240523A1 FACTOR XIa INHIBITORS Public/Granted day:2017-08-24
Information query
