Invention Grant
- Patent Title: Ultra-pure agonists of guanylate cyclase C, method of making and using same
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Application No.: US14896019Application Date: 2014-06-05
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Publication No.: US10011637B2Publication Date: 2018-07-03
- Inventor: Kunwar Shailubhai , Stephen Comiskey , Rong Feng , Juncai Bai , Ruoping Zhang , Jun Jia , Junfeng Zhou , Qiao Zhao , Guoqing Zhang
- Applicant: Synergy Pharmaceuticals, Inc.
- Applicant Address: US NY New York
- Assignee: SYNERGY PHARMACEUTICALS, INC.
- Current Assignee: SYNERGY PHARMACEUTICALS, INC.
- Current Assignee Address: US NY New York
- Agency: Cooley LLP
- Agent Cynthia A. Kozakiewicz; Ivor Elrifi
- International Application: PCT/US2014/041143 WO 20140605
- International Announcement: WO2014/197720 WO 20141211
- Main IPC: C07K1/14
- IPC: C07K1/14 ; C07K7/08 ; C12N9/88 ; B01D15/42
Abstract:
The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.
Public/Granted literature
- US20160145307A1 ULTRA-PURE AGONISTS OF GUANYLATE CYCLASE C, METHOD OF MAKING AND USING SAME Public/Granted day:2016-05-26
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