Bridged bicyclic nucleosides
Abstract:
The present invention relates to 2′-C-Bridged Bicyclic Nucleosides and Nucleotides, and oligonucleotides comprising at least one 2′-C-Bridged Bicyclic Nucleotides. The present invention further provides pharmaceutical compositions comprising the nucleosides, nucleotides, and oligonucleotides, as well as their respective methods of use and synthesis.
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