Certain aspects relate to systems and techniques for performing local intensity equalization on images in a set of images exhibiting local intensity variations. For example, the local intensity equalization can be used to perform accurate region matching and alignment of the images. The images can be partitioned into regions of pixel blocks, for instance based on location, shape, and size of identified keypoints in the images. Regions depicting the same feature in the images can be equalized with respect to intensity. Region matching based on the keypoints in the intensity-equalized regions can be performed with accuracy even in images captured by asymmetric sensors or exhibiting spatially varying intensity.