Acoustic echo cancellation (AEC) processing may be improved by performing echo cancellation using a combined multi-channel reference signal. Two or more reference signals, such as a left and right channel of a stereo source, may be combined and provided to an AEC block configured to receive the combined signal and perform AEC processing using the combined signal. The AEC block may include an adaptive filter that performs operations that cause pre-whitening of the combined reference signal and de-correlation of the individual channels within the combined reference signal. The pre-whitening of the signal flattens the spectrum of the combined reference signal, which may improve convergence speed of the AEC processing in cancelling the echo. The de-correlating of the signal cancels inter-channel correlation between the multiple channels, which may improve convergence speed of the AEC processing in cancelling the echo.