Invention Grant
- Patent Title: TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs)
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Application No.: US15374272Application Date: 2016-12-09
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Publication No.: US10016412B2Publication Date: 2018-07-10
- Inventor: David Spiegel , Kelly Fitzgerald
- Applicant: YALE UNIVERSITY
- Applicant Address: US CT New Haven
- Assignee: YALE UNIVERSITY
- Current Assignee: YALE UNIVERSITY
- Current Assignee Address: US CT New Haven
- Agent Henry D. Coleman; R. Neil Sudol
- Main IPC: A61K31/56
- IPC: A61K31/56 ; A61K31/4745 ; A61K47/48 ; C07D471/04

Abstract:
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) and Toll-like receptor agonist (TLR) through a linker and a multifunctional connector group or molecule.
Public/Granted literature
- US20170087148A1 TLR-AGONIST-CONJUGATED ANTIBODY RECRUITING MOLECULES (TLR-ARMs) Public/Granted day:2017-03-30
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