Invention Grant
- Patent Title: Antigenic epitopes from EBV gp350/220 and uses thereof
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Application No.: US15116968Application Date: 2015-02-06
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Publication No.: US10016494B2Publication Date: 2018-07-10
- Inventor: Caroline Alfieri , Jerome Tanner , Jing Hu , Jurgen Sygusch , Mathieu Coinçon
- Applicant: VALORISATION-HSJ, LIMITED PARTNERSHIP , VALORISATION-RECHERCHE, LIMITED PARTNERSHIP
- Applicant Address: CA Montreal CA Montreal
- Assignee: VALORISATION-HSJ, LIMITED PARTNERSHIP,VALORISATION-RECHERCHE, LIMITED PARTNERSHIP
- Current Assignee: VALORISATION-HSJ, LIMITED PARTNERSHIP,VALORISATION-RECHERCHE, LIMITED PARTNERSHIP
- Current Assignee Address: CA Montreal CA Montreal
- Agent Alain Dumont
- International Application: PCT/CA2015/050089 WO 20150206
- International Announcement: WO2015/117244 WO 20150813
- Main IPC: A61K39/245
- IPC: A61K39/245 ; C07K14/05 ; A61K39/12 ; G01N33/68 ; G01N33/569 ; C07K16/08

Abstract:
The present invention relates to a peptide comprising (A) (i) a first domain comprising an amino acid sequence having at least 60% sequence similarity with the sequence PDDRTLQ (SEQ ID NO:1); and (ii) a second domain covalently linked to the first domain and comprising an amino acid sequence having at least 60% sequence similarity with the sequence QNPVYLIPETVPYIKWDN (SEQ ID NO:2) or (B) (i) a first domain comprising an amino acid sequence having at least 60% sequence similarity with the sequence GSAKPGNGSYF (SEQ ID NO: 41); and (ii) a second domain covalently linked to the first domain, said second domain comprising an amino acid sequence having at least 60% sequence similarity with the sequence SVKTEMLGNEID (SEQ ID NO: 42), wherein the peptide binds to monoclonal antibody clone 72A1. This peptide may be useful for inducing the production of neutralizing antibodies against a gp350-expressing herpesvirus, such as Epstein-Barr virus (EBV), for example for immunizing or vaccinating an animal against a gp350-expressing herpesvirus, as well as for detecting the presence or absence neutralizing anti-gp350-expressing herpesvirus antibodies in a sample.
Public/Granted literature
- US20170189517A1 ANTIGENIC EPITOPES FROM EBV gp350/220 AND USES THEREOF Public/Granted day:2017-07-06
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