The present invention relates to an immunogenic composition comprising a continuous aqueous phase and a dispersed phase as droplets and comprising: an amphiphilic lipid, a solubilizing lipid comprising at least one fatty acid glyceride, a co-surfactant comprising at least one chain consisting of alkylene oxide units, a surfactant bearing an antigen of the following formula (I): (L1-X1—H1—Y1)v-G-Z1—Ag  (I), to its preparation method and its uses, notably for producing antibodies, as a drug or in an immunization method.