Invention Grant
- Patent Title: Hydrate of 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride, preparation method and use of the same
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Application No.: US15561730Application Date: 2016-03-02
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Publication No.: US10017472B2Publication Date: 2018-07-10
- Inventor: Jinfeng Song , Xungui He , Wensheng Tang , Yuan Wang
- Applicant: 2Y-CHEM, LTD.
- Applicant Address: CN Shanghai
- Assignee: 2Y-CHEM, LTD.
- Current Assignee: 2Y-CHEM, LTD.
- Current Assignee Address: CN Shanghai
- Agency: Carter, DeLuca, Farrell & Schmidt, LLP
- Priority: CN201510136779 20150326
- International Application: PCT/CN2016/075354 WO 20160302
- International Announcement: WO2016/150283 WO 20160929
- Main IPC: C07D213/26
- IPC: C07D213/26 ; C07D401/12 ; C07D211/18 ; B01D9/00
Abstract:
The present invention relates to 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate and a preparation method of the same. The 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate has a very good crystal form and is well suitable for recrystallization purification; further, the effect of impurity removal effect is very good, and any single impurity can be controlled less than 0.1%.
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