- Patent Title: Crystalline forms of a BACE inhibitor, compositions, and their use
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Application No.: US15514584Application Date: 2015-09-25
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Publication No.: US10017505B2Publication Date: 2018-07-10
- Inventor: Scott Trzaska , Zachary E. Dance , Yong Liu , Richard John Varsolona , Gregory York
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Keith D. MacMillan; Catherine D. Fitch
- International Application: PCT/US2015/052096 WO 20150925
- International Announcement: WO2016/053767 WO 20160407
- Main IPC: C07D417/12
- IPC: C07D417/12 ; C07C309/30
Abstract:
The present invention provides four crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.
Public/Granted literature
- US20170233383A1 NOVEL CRYSTALLINE FORMS OF A BACE INHIBITOR, COMPOSITIONS, AND THEIR USE Public/Granted day:2017-08-17
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