Invention Grant
- Patent Title: Computationally optimized broadly reactive antigens for H1N1 influenza
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Application No.: US15392710Application Date: 2016-12-28
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Publication No.: US10017544B2Publication Date: 2018-07-10
- Inventor: Ted M. Ross , Corey J. Crevar , Donald M. Carter, Jr.
- Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- Main IPC: C07K14/005
- IPC: C07K14/005 ; A61K39/145 ; A61K9/00 ; A61K39/00
Abstract:
Generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates are described. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2012. Optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides are described, as are codon-optimized nucleic acid sequences encoding the HA polypeptides and methods of eliciting an immune response against influenza virus in a subject.
Public/Granted literature
- US20170114102A1 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA Public/Granted day:2017-04-27
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