A method for operating an internal combustion engine is provided. The internal combustion engine has a compressor for adjusting a charge density in an intake pipe of the internal combustion engine and has an adjusting device, such as a variable valve gear, for adjusting a volumetric efficiency of the internal combustion engine. A dynamic setpoint quantity for the internal combustion engine is determined as a function of a difference between a load demand upon the internal combustion engine and a current load output of the internal combustion engine. The volumetric efficiency and the charge density are adjusted as a function of the dynamic setpoint quantity. An internal combustion engine and a vehicle are also provided.