Invention Grant
- Patent Title: Correlation of disease activity with clonal expansions of human papillomavirus 16-specific CD8+ T-cells in patients with severe erosive oral lichen planus
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Application No.: US14910612Application Date: 2014-08-08
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Publication No.: US10018629B2Publication Date: 2018-07-10
- Inventor: Marie-Lise Gougeon , Manuelle Viguier , Hervé Bachelez , Nicolas Fazilleau
- Applicant: INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE PARIS DIDEROT PARIS 7 , ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
- Applicant Address: FR Paris FR Paris FR Paris FR Paris
- Assignee: INSTITUTE PASTEUR,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),UNIVERSITE PARIS DIDEROT-PARIS 7,ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
- Current Assignee: INSTITUTE PASTEUR,INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),UNIVERSITE PARIS DIDEROT-PARIS 7,ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
- Current Assignee Address: FR Paris FR Paris FR Paris FR Paris
- Agency: Arrigo, Lee, Guttmann & Mouta-Bellum LLP
- International Application: PCT/EP2014/067131 WO 20140808
- International Announcement: WO2015/018943 WO 20150212
- Main IPC: C07K14/025
- IPC: C07K14/025 ; G01N33/569 ; A61K39/12 ; C07K14/005 ; C07K14/235 ; C12N7/00 ; C12Q1/04 ; C12Q1/6869 ; A61K31/675 ; A61K39/02 ; A61K45/06 ; A61N5/06 ; C12Q1/70 ; G01N33/50 ; A61K39/00
Abstract:
A massive clonal expansion of activated CD8+ T-cells with increased frequency of HPV 16-specific CD8+ T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.
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