Systems and methods for pixel streaming a stream-enabled application to a client device that is executed on an intermediary client device virtualization system. Portions of a stream-enabled application are used to begin execution of the stream-enabled application on the client device virtualization system. The output of the beginning of execution of the stream-enabled application are used to generate a pixel based stream-enabled application stream. The pixel-based stream-enabled application stream is sent to the client device. User interactions in response to the display of the stream are represented in user interaction data. The user interaction is determined from the user interaction data and application execution commands are determined based on the determined user interaction. Continued execution of the stream-enabled application occurs based on the application execution commands. The pixel-based stream-enabled application stream is modified according to the continued execution of the stream-enabled application.