Invention Grant
- Patent Title: Stabilized antibody-containing liquid formulations
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Application No.: US13522848Application Date: 2011-01-20
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Publication No.: US10022319B2Publication Date: 2018-07-17
- Inventor: Tomoyuki Igawa , Chifumi Moriyama
- Applicant: Tomoyuki Igawa , Chifumi Moriyama
- Applicant Address: JP Tokyo
- Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
- Current Assignee: CHUGAI SEIYAKU KABUSHIKI KAISHA
- Current Assignee Address: JP Tokyo
- Agency: Nixon & Vanderhye P.C.
- Priority: JP2010-010060 20100120
- International Application: PCT/JP2011/050911 WO 20110120
- International Announcement: WO2011/090088 WO 20110728
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K9/00 ; A61K47/12 ; A61K47/18

Abstract:
An objective of the present invention is to provide stable antibody-containing formulations which are suitable for subcutaneous administration and in which aggregation formation is suppressed during long-term storage.The present inventors discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid as a counter ion species in histidine buffer or tris(hydroxymethyl)aminomethane, specifically by using histidine-aspartate buffer or histidine-glutamate buffer, or tris(hydroxymethyl)aminomethane-aspartate or tris(hydroxymethyl)aminomethane-glutamate as a buffer. The present inventors also discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid, as a counter ion species to a basic amino acid such as arginine, specifically by using arginine-aspartate or arginine-glutamate.
Public/Granted literature
- US20130022625A1 Stabilized Antibody-Containing Liquid Formulations Public/Granted day:2013-01-24
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