Invention Grant
- Patent Title: Methods, compositions, and kits for improving pancreatic beta cell viability and treating diseases or conditions related to beta cell destruction
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Application No.: US14659568Application Date: 2015-03-16
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Publication No.: US10022403B2Publication Date: 2018-07-17
- Inventor: Sanjay Awasthi , Sushma Yadav , Ismail Al Abdullah , Fouad Kandeel , Brian McFadden , Indu Nair , Sharad S. Singhal
- Applicant: CITY OF HOPE
- Applicant Address: US CA Duarte
- Assignee: CITY OF HOPE
- Current Assignee: CITY OF HOPE
- Current Assignee Address: US CA Duarte
- Agency: Perkins Coie LLP
- Main IPC: A61K35/39
- IPC: A61K35/39 ; C12N5/071 ; A61K38/45 ; C12N9/10
Abstract:
The present disclosure provides novel methods for increasing β-cell viability in islets by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to the islets. The disclosure also provides novel methods for treating a disease or condition in a subject, such as type 1 diabetes mellitus, by delivering RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, to islets and transplanting the islets into the subject to treat the disease or condition. Kits and compositions including RLIP76 polypeptides or GSTA4 polypeptides, or a combination thereof; or RLIP76 polynucleotides or GSTA4 polynucleotides, or a combination thereof, are also provided to increase β-cell viability.
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