Invention Grant
- Patent Title: Regulation of specific spinal neurons regulating pain transmission via chimeric toxins
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Application No.: US15241221Application Date: 2016-08-19
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Publication No.: US10022450B2Publication Date: 2018-07-17
- Inventor: Eric A. Johnson , Sabine Pellett , William H. Tepp , Tony L. Yaksh , Marc Marino , Qinghao Xu
- Applicant: Wisconsin Alumni Research Foundation , The Regents of the University of California
- Applicant Address: US WI Madison US CA Oakland
- Assignee: Wisconsin Alumni Research Foundation,The Regents of the University of California
- Current Assignee: Wisconsin Alumni Research Foundation,The Regents of the University of California
- Current Assignee Address: US WI Madison US CA Oakland
- Agency: Quarles & Brady LLP
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K39/08 ; C07K14/33 ; A61K47/48 ; C12N9/96 ; C07K7/22 ; C07K14/575 ; C07K14/70 ; C07K14/72 ; A61K38/48 ; A61K9/00 ; A61K47/62
Abstract:
A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
Public/Granted literature
- US20160361429A1 Regulation of Specific Spinal Neurons Regulating Pain Transmission Public/Granted day:2016-12-15
Information query
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