Invention Grant
- Patent Title: Functionalized phosphorodiamites for therapeutic oligonucleotide synthesis
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Application No.: US14182004Application Date: 2014-02-17
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Publication No.: US10022454B2Publication Date: 2018-07-17
- Inventor: Scott G. Petersen
- Applicant: Scott G. Petersen
- Applicant Address: US DE Wilmington
- Assignee: LipoSciences, LLC
- Current Assignee: LipoSciences, LLC
- Current Assignee Address: US DE Wilmington
- Agency: Law Office of Timothy M. Brown
- Main IPC: C07H19/04
- IPC: C07H19/04 ; C07H21/02 ; C12N15/11 ; C12N5/071 ; A61K31/70 ; A61K31/7088 ; A61K47/64 ; A61K31/713
Abstract:
Disclosed herein are compositions and methods for generating ribo-nucleic neutral (RNN) or deoxyribo-nucleic-neutral (DNN) polynucleotides with reduced anionic charge, for improved intracellular delivery. Also disclosed herein are methods of using RNN and DNN compositions.
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