A fluid injection system including an injector head having a syringe for delivering a fluid to a patient, a mounting structure pivotally connected to the injector head and configured to support the injector head above a surface, and a control system operationally coupled to the injector head for controlling an injection procedure is disclosed. The fluid injection system is provided with sensors to control various aspects of the fluid injection system, such as the establishment of a reference plane, the determination of a tilt angle of the injector head, and the determination of a temperature of an actuation system of the injector head.