Some embodiments are directed to a seal assembly including a main door seal that extends around a vehicle door interior surface and that is spaced from a door perimeter. A first seal portion extends from an inward end thereof disposed along the main door seal to an outward end thereof disposed along the vehicle door perimeter. The first seal portion forms a barrier vertically above a latch slot, is capable of intercepting substances disposed above and traveling downward toward the latch slot, and facilitates transport of the intercepted substances to the door perimeter. A second seal portion is disposed between the latch slot and the vehicle door perimeter, and extends downwardly from the outward end of the first seal portion. The second seal portion is configured to impede travel toward the vehicle door interior surface of the intercepted substances that have been transported to the vehicle door perimeter.