A vehicle occupant protection device includes a front airbag and a lateral airbag. The front airbag is provided in a vehicle body and deploys in front of an occupant boarding the vehicle body so that at least a head of the occupant hits against the front airbag. The lateral airbag is provided in the vehicle body so as to deploy at a lateral side of the occupant. The lateral airbag has a protrusion that deploys toward a middle of the vehicle body in a width direction. The protrusion is deployed together with the front airbag so that the head of the occupant hitting against the front airbag is supported from front and lateral sides.