Invention Grant
- Patent Title: Substituted aromatic compounds and related method for the treatment of fibrosis
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Application No.: US14776328Application Date: 2014-03-14
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Publication No.: US10023518B2Publication Date: 2018-07-17
- Inventor: Boulos Zacharie , Shaun Abbott , Lyne Gagnon , Pierre Laurin , Brigitte Grouix
- Applicant: PROMETIC BIOSCIENCES INC.
- Applicant Address: GB Cambridge
- Assignee: PROMETIC PHARMA SMT LIMITED
- Current Assignee: PROMETIC PHARMA SMT LIMITED
- Current Assignee Address: GB Cambridge
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/CA2014/000236 WO 20140314
- International Announcement: WO2014/138906 WO 20140918
- Main IPC: C07C53/134
- IPC: C07C53/134 ; A61K31/192 ; C07C59/52 ; C07C57/30 ; C07C57/58

Abstract:
The present invention relates to compounds of: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R1 is H, F or OH; R2 is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)—(CH2)n—CH3 or CH(OH)—(CH2)n—CH3 wherein n is 3 or 4; R3 is H, F, OH or CH2Ph; R4 is H, F or OH; Q is 1) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)—C(O)OH, 5) CF2—C(O)OH, or 6) C(O)—C(O)OH; and compositions comprising the same and the method using the same for the prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis, renal fibrosis, pancreas fibrosis, systemic sclerosis, cardiac fibrosis or macular degeneration.
Public/Granted literature
- US20160039736A1 Substituted Aromatic Compounds and Related Method for the Treatment of Fibrosis Public/Granted day:2016-02-11
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