Invention Grant
- Patent Title: Glutathione-cleavable prodrug and methods of use thereof
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Application No.: US15573183Application Date: 2016-05-12
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Publication No.: US10023551B2Publication Date: 2018-07-17
- Inventor: Milton L. Brown , Yali Kong , Jacqueline Smith , Kan Wang , Shujie Hou
- Applicant: GEORGETOWN UNIVERSITY
- Applicant Address: US DC Washington
- Assignee: Georgetown University
- Current Assignee: Georgetown University
- Current Assignee Address: US DC Washington
- Agency: Kilpatrick Townsend & Stockton, LLP
- International Application: PCT/US2016/032088 WO 20160512
- International Announcement: WO2016/183315 WO 20161117
- Main IPC: C07D311/58
- IPC: C07D311/58 ; C07D311/02 ; A61P35/00 ; G01N21/64 ; A61K47/69 ; C07C321/14 ; C07C69/017 ; C07C69/003 ; C07C271/28
Abstract:
A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.
Public/Granted literature
- US20180105505A1 GLUTATHIONE-CLEAVABLE PRODRUG AND METHODS OF USE THEREOF Public/Granted day:2018-04-19
Information query
