Invention Grant
- Patent Title: G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
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Application No.: US15501888Application Date: 2015-08-10
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Publication No.: US10023564B2Publication Date: 2018-07-17
- Inventor: Scott D. Larsen , Kristoff Homan , Helen Waldschmidt , John J. G. Tesmer
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2015/044468 WO 20150810
- International Announcement: WO2016/023028 WO 20160211
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D405/14
Abstract:
Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Public/Granted literature
- US20170240538A1 G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME Public/Granted day:2017-08-24
Information query
