Invention Grant
- Patent Title: Dasatinib salts
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Application No.: US15314255Application Date: 2015-05-26
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Publication No.: US10023566B2Publication Date: 2018-07-17
- Inventor: Ede Laszlo Marvanyos , Attila Virag , Tamas Gregor , Balazs Volk , Maria Tothne Lauritz , Laszlo Pongo , Balazs Peregi , Gyula Lukacs , Zoltan Varga , Andras Dancso
- Applicant: EGIS GYOGYSZERGYAR ZRT
- Applicant Address: HU Budapest
- Assignee: EGIS GYOGYSZERGYAR ZRT
- Current Assignee: EGIS GYOGYSZERGYAR ZRT
- Current Assignee Address: HU Budapest
- Agency: Millen White Zelano and Branigan, PC
- Agent Csaba Henter
- Priority: HU1400264 20140526
- International Application: PCT/HU2015/000049 WO 20150526
- International Announcement: WO2015/181573 WO 20151203
- Main IPC: C07D417/12
- IPC: C07D417/12

Abstract:
The invention relates to normal or acidic salts of dasatinib and the hydrate and solvate forms thereof. More specifically the invention concerns: dasatinib cyclamic acid salt, dasatinib cyclamic acid (1:1) salt Form I, dasatinib cyclamic acid (1:1) salt Form II, dasatinib hydrogen bromide (1:2) salt, dasatinib methane sulfonic acid (1:2) salt, dasatinib p-toluenesulfonic acid (1:1) dihydrate salt, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form I, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form II, dasatinib p-toluenesulfonic acid (1:1) salt methanol solvate. Moreover the invention relates process for preparing dasatinib salts, pharmaceutical compositions comprising thereof and the use of dasatinib salts the treatment of cancer.
Public/Granted literature
- US20170183334A1 DASATINIB SALTS Public/Granted day:2017-06-29
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