- Patent Title: Methods of preparing inhibitors of influenza viruses replication
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Application No.: US15150476Application Date: 2016-05-10
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Publication No.: US10023569B2Publication Date: 2018-07-17
- Inventor: Gerald J. Tanoury , William Aloysius Nugent , Vadims Dvornikovs , Peter Jamison Rose
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Andrew N. Weber; Jonathan P. O'Brien
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/506 ; B01J31/04

Abstract:
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: comprises: (a) reacting Compound (X): or a pharmaceutically acceptable salt thereof with Compound (Y): in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20160251354A1 METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION Public/Granted day:2016-09-01
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