Invention Grant
- Patent Title: Pyrrolopyrimidine compounds, use as inhibitors of the kinase LRRK2, and methods for preparation thereof
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Application No.: US15382213Application Date: 2016-12-16
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Publication No.: US10023579B2Publication Date: 2018-07-17
- Inventor: Corinne E. Augelli-Szafran , Mark Suto , Robert Galemmo , Omar Moukha-Chafiq , Vandana Gupta , Subramaniam Ananthan
- Applicant: Southern Research Institute
- Applicant Address: US AL Birmingham
- Assignee: Southern Research Institute
- Current Assignee: Southern Research Institute
- Current Assignee Address: US AL Birmingham
- Agency: Ballard Spahr LLP
- Main IPC: C07D487/14
- IPC: C07D487/14
Abstract:
The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (LRRK2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal LRRK2 kinase activity. Compounds of the present disclosure can be used to treat disorders including neurodegenerative diseases such as Parkinson's disease; precancerous conditions and cancer; autoimmune disorders such as Crohn's disease, rheumatoid arthritis and psoriasis; and leprosy (Hansen's disease). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Public/Granted literature
- US20170174694A1 PYRROLOPYRIMIDINE COMPOUNDS, USE AS INHIBITORS OF THE KINASE LRRK2, AND METHODS FOR PREPARATION THEREOF Public/Granted day:2017-06-22
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