Invention Grant
- Patent Title: Hydrolysis resistant sialic acid derivatives and methods for their use
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Application No.: US15119622Application Date: 2015-02-18
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Publication No.: US10023601B2Publication Date: 2018-07-17
- Inventor: Stephen G. Withers , Thomas J. Morley , Lars Baumann
- Applicant: The University of British Columbia
- Applicant Address: CA Vancouver
- Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
- Current Assignee: THE UNIVERSITY OF BRITISH COLUMBIA
- Current Assignee Address: CA Vancouver
- Agency: Saliwanchik, Lloyd & Eisenschenk
- International Application: PCT/CA2015/000096 WO 20150218
- International Announcement: WO2015/123756 WO 20150827
- Main IPC: C07H13/02
- IPC: C07H13/02 ; C12P21/00 ; C07K1/107 ; C07H5/02 ; C08H1/00
Abstract:
This invention provides compound having a structure of Formulas: Furthermore, methods and uses of such compounds for covalently bonding to a sugar acceptor, to form modified protein therapeutics having reduced enzymatic hydrolysis, improved biological stability or an improved pharmacokinetic property.
Public/Granted literature
- US20170121361A1 Hydrolysis Resistant Sialic Acid Derivatives and Methods for Their Use Public/Granted day:2017-05-04
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