Invention Grant
- Patent Title: Method of treating endometriosis
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Application No.: US14355698Application Date: 2012-11-01
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Publication No.: US10023612B2Publication Date: 2018-07-17
- Inventor: Mark Eccleston , Satu Vainikka , George Steven Morris
- Applicant: ValiRx PLC
- Applicant Address: GB London
- Assignee: VALIRX PLC
- Current Assignee: VALIRX PLC
- Current Assignee Address: GB London
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Priority: GB1118831.5 20111101
- International Application: PCT/GB2012/052722 WO 20121101
- International Announcement: WO2013/064830 WO 20130510
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K7/06 ; C07K5/097 ; C07K7/08 ; G01N33/68 ; C07K5/117 ; C07K16/18 ; C07K16/28 ; A61K47/64

Abstract:
The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in preventing or treating a non-cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject, or for use in preventing or treating a cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject who wishes to preserve fertility, or for use in preventing or treating a gynecological condition in which an activity of AR and/or ER is a contributory factor in a subject. Preferably, the molecule comprises or consists of the structure: Bj[(Pro)n-Xr-His-Pro-His-Ala-Arg-lle-Lys]m-Rp, or Bj[lys-ile-arg-ala-his-pro-his-xr-(pro)n]m-Rp, or a derivative or fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, m is an integer from 1 to 3, R is a second chemical moiety, p is 0 or 1, and [lys-ile-arg-ala-his-pro-his-xr-(pro)n] is the retro-inverso peptide of [(Pro)n-Xr-His-Pro-His-Ala-Arg-Ile-Lys].
Public/Granted literature
- US20140322306A1 Medical Use Public/Granted day:2014-10-30
Information query
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