Invention Grant
- Patent Title: Engineered high-affinity human T cell receptors
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Application No.: US15037476Application Date: 2014-11-21
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Publication No.: US10023625B2Publication Date: 2018-07-17
- Inventor: Sheena N. Smith , Daniel T. Harris , David M. Kranz
- Applicant: The Board of Trustees of the University of Illinois
- Applicant Address: US IL Urbana
- Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee Address: US IL Urbana
- Agency: Cooley LLP
- International Application: PCT/US2014/066892 WO 20141121
- International Announcement: WO2015/077607 WO 20150528
- Main IPC: A61K36/00
- IPC: A61K36/00 ; C07K14/725 ; C07K14/47 ; A61K38/00

Abstract:
T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of mutational libraries of TCRs in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast (i.e. directed evolution). In embodiments, the engineered TCRs can be used in soluble form for targeted delivery in vivo, or as genes introduced into T cells in an adoptive T cell setting.
Public/Granted literature
- US20160280755A1 ENGINEERED HIGH-AFFINITY HUMAN T CELL RECEPTORS Public/Granted day:2016-09-29
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