Invention Grant
- Patent Title: Microbial approach for the production of 5-hydroxytryptophan
-
Application No.: US15310040Application Date: 2015-05-14
-
Publication No.: US10023889B2Publication Date: 2018-07-17
- Inventor: Yajun Yan , Yuheng Lin
- Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
- Applicant Address: US GA Athens
- Assignee: University of Georgia Research Foundation, Inc.
- Current Assignee: University of Georgia Research Foundation, Inc.
- Current Assignee Address: US GA Athens
- Agency: Mueting, Raasch & Gebhardt, P.A.
- International Application: PCT/US2015/030811 WO 20150514
- International Announcement: WO2015/175793 WO 20151119
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12P13/22 ; C12N9/02 ; C12N9/88 ; C12N9/06 ; A23L2/52 ; A23K20/10
Abstract:
5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5-hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.
Public/Granted literature
- US20170240939A1 MICROBIAL APPROACH FOR THE PRODUCTION OF 5-HYDROXYTRYPTOPHAN Public/Granted day:2017-08-24
Information query
IPC分类:
