Invention Grant
- Patent Title: Cancer-related extracellular matrix signatures and related methods and products
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Application No.: US15272870Application Date: 2016-09-22
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Publication No.: US10024860B2Publication Date: 2018-07-17
- Inventor: Richard O. Hynes , Alexandra Naba , Karl Clauser , Steven A. Carr , Kenneth Tanabe
- Applicant: Massachusetts Institute of Technology , The General Hospital Corporation , The Broad Institute, Inc.
- Applicant Address: US MA Cambridge US MA Boston US MA Cambridge
- Assignee: Massachusetts Institute of Technology,The General Hospital Corporation,The Broad Institute, Inc.
- Current Assignee: Massachusetts Institute of Technology,The General Hospital Corporation,The Broad Institute, Inc.
- Current Assignee Address: US MA Cambridge US MA Boston US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: G01N33/574
- IPC: G01N33/574 ; A61K49/00 ; A61K51/00 ; A61K47/68 ; A61K51/10
Abstract:
Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with various aspects of cancer. Panels or signature sets of proteins useful in the detection, diagnosis and treatment of cancers as well as monitoring therapeutic progress in a cancer patient are provided herein along with methods for their detection and for their use in targeting imaging and/or therapeutic agents to the tumors via binding to the specified proteins. The proteins were identified using proteomics analyzes of tissue samples taken from cancer patients. In certain aspects the proteins are particularly useful in colon cancer patients.
Public/Granted literature
- US20170343553A9 CANCER-RELATED EXTRACELLULAR MATRIX SIGNATURES AND RELATED METHODS AND PRODUCTS Public/Granted day:2017-11-30
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