Invention Grant
- Patent Title: Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer
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Application No.: US14104860Application Date: 2013-12-12
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Publication No.: US10024862B2Publication Date: 2018-07-17
- Inventor: Carolyn W. Hitko , Thomas Kirkland , Thomas Machleidt , Rachel Friedman Ohana , Matt Robers , Keith Wood
- Applicant: Promega Corporation
- Applicant Address: US WI Madison
- Assignee: Promega Corporation
- Current Assignee: Promega Corporation
- Current Assignee Address: US WI Madison
- Agency: Casimir Jones SC
- Agent David W. Staple
- Main IPC: G01N33/58
- IPC: G01N33/58 ; G01N33/50 ; G01N33/542
Abstract:
The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, or portions, components, or subunits of bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.
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