An information processing apparatus includes an input unit, an output unit, a change amount determination unit, and an instruction unit. The input unit is configured to input a measured temperature that is a measured value of a temperature of a measurement point. The output unit is configured to output a manipulated variable to a temperature control mechanism configured to control the temperature of the measurement point to be a set temperature, the manipulated variable being used for controlling the set temperature. The change amount determination unit is configured to determine an amount of temporal change of the input measured temperature. The instruction unit is configured to instruct the output unit to output a unit manipulated variable with a predetermined manipulated variable as a unit, based on a determination by the change amount determination unit.