In embodiments of physics-based cell layout redesign, a computing device displays a cell layout interface that includes cells in a cell grid, and the computing device implements a physics-based algorithm as a computer application that can receive a redesign input to manipulate a cell in the cell layout interface. The physics-based algorithm is implemented to then determine one or more of the cells that are proximate the manipulated cell based on edge relations between an edge of the manipulated cell and respective edges of the one or more cells. The physics-based algorithm can then reconfigure the one or more proximate cells based on the redesign input to the manipulated cell and the edge relations between the edges of the cells.