A method includes magnifying a pathology sample with a microscope to form magnified pathology images, and recording the magnified pathology images with a digital camera optically coupled to the microscope. The method also includes comparing the magnified pathology images to reference pathology images included in a pathology database to identify one or more regions of interest in the magnified pathology images. A user of the microscope is alerted to the one or more regions of interest in the magnified pathology images.