A system-on-chip and an electronic device including the system-on-chip are provided. The system-on-chip includes a power switch, a logic block, a memory device, and a buffer. The power switch is coupled between a first power supply line and a virtual power supply line, and turns on in response to a switch control signal. The logic block is coupled between the virtual power supply line and a ground line. The memory device is coupled between a second power supply line and the ground line. The buffer is coupled between the second power supply line and the ground line, and generates the switch control signal based on a sleep signal.