Disclosed are: a frame for secondary batteries, which ensures a channel around cooling plates stably to improve cooling efficiency for secondary batteries; and a battery module, a battery pack and a vehicle comprising the same. A frame for secondary batteries according to the present disclosure comprises: an upper cooling plate and a lower cooling plate having a plate shape and arranged to be spaced apart by a predetermined distance from each other facing each other; a main frame having four sides and configured to encompass the outer peripheral portions of the upper cooling plate and the lower cooling plate, to mount the outer peripheral portions of pouch-type secondary batteries thereto, and to enable two or more main frames to be stacked; and a support member arranged between the upper cooling plate and the lower cooling to support both cooling plates.