Systems and techniques for network on a chip based computer architectures and communications therein are described. A described technique includes generating, at a first computing resource of a computer system, a chained packet sequence. A packet therein can specify a chain indicator to indicate inclusion in the chained packet sequence, a destination address, and an opcode. The technique includes routing the sequence to a second computing resource based on the destination address of a first chained packet in the sequence. The technique includes receiving the sequence at the second computing resource; performing the operation specified by the opcode of the first chained packet; and determining whether to process or forward one or more chained packets in a remainder portion of the sequence based on the destination address of a second chained packet of the sequence, the second chained packet being located at a beginning of the remainder portion.