Invention Grant
- Patent Title: Serpina1 iRNA compositions and methods of use thereof
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Application No.: US15399820Application Date: 2017-01-06
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Publication No.: US10030244B2Publication Date: 2018-07-24
- Inventor: Alfica Sehgal , Klaus Charisse , Brian Bettencourt , Martin Maier , Kallanthottathil G. Rajeev , Gregory Hinkle , Muthiah Manoharan
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Maria Laccotripe Zacharakis; Deborah L. Nagle
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/113 ; A61K31/712 ; A61K31/713
Abstract:
The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.
Public/Granted literature
- US20170114342A1 SERPINA1 iRNA COMPOSITIONS AND METHODS OF USE THEREOF Public/Granted day:2017-04-27
Information query
