An interface card fastening module is provided for assembling an interface card to a housing and for electrically connecting the interface card with a main board, wherein the main board has an interface card insertion slot corresponding to the interface card, and a plane defined extendingly from an opening of the interface card insertion slot is substantially parallel to the main board. The interface card fastening module includes an engaging member disposed at the housing so as to be movable between a release position and an engage position, wherein the engaging member comprising a body, at least one lock portion, and an extension plate. A first clamping portion is disposed at a side wall of the housing, and a second clamping portion is disposed at a base plate of the housing in which the base plate is perpendicular to the side wall of the housing.