A method for operating at least a first of a plurality of co-located, non-time synchronous radios at a first location communicating data by frames with one or more other remote radios at a second and optionally additional locations in a wireless communication system, to synchronize first or uplink and/or second or downlink frame portions of the frames to mitigate interference between the co-located radios. A frame table of attributes of uplink and/or downlink frame portions associated with frames of the first radio is stored. The spectral content of transmissions from at least a second of the co-located radios is monitored. Based on the monitored spectral content, characteristics for uplink and/or downlink frame portions of the first co-located radio to mitigate interference with the at least second co-located radio are determined. Attributes in the frame table to enable interference-optimized uplink and/or downlink portions of frames of the first co-located radio are updated.