Disclosed are a method and apparatus for transmitting and receiving data using a Bluetooth low energy (BLE) technology. A method of transmitting or receiving data using Bluetooth low energy (BLE) in a wireless communication system includes forming Bluetooth LE connection with a second device, establishing an isochronous channel for transmitting an audio packet with the second device and transmitting audio packets to the second device through the isochronous channel using an interleaved method at a specific channel interval. The sequence in which the audio packets are transmitted may be determined regardless of whether acknowledgement (ACK) for each of the audio packets is received from the second device.